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SB 290157
CAS No. 259218-28-5
SB 290157 ( SB-290157 | SB290157 )
产品货号. M13784 CAS No. 259218-28-5
一种有效的、选择性的过敏毒素 C3a 受体 (C3aR) 非肽拮抗剂，IC50 为 200 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SB 290157
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的、选择性的过敏毒素 C3a 受体 (C3aR) 非肽拮抗剂，IC50 为 200 nM。
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产品描述A potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM; does not antagonize the C5aR or 5 other chemotactic GPCRs on human neutrophils; blocks C3a-induced C3aR internalization and C3a-induced Ca(2+) mobilization in RBL-C3aR cells and human neutrophils with IC50 of 27.7 and 28 nM, respectively; also inhibits C3a-induced Ca2+ mobilization of mouse and guinea pig C3aRS with IC50 of 7 and 12.5 nM, respectively; potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery, demonstrates antiinflammatory activity in animal models.
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体外实验——
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体内实验——
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同义词SB-290157 | SB290157
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通路Immunology/Inflammation
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靶点Complement System
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受体Complement System
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研究领域——
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适应症——
化学信息
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CAS Number259218-28-5
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分子量412.49
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分子式C22H28N4O4
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称N(2)-[(2,2-diphenylethoxy)acetyl]-L-arginine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ames RS, et al. J Immunol. 2001 May 15;166(10):6341-8.
2. Therien AG. J Immunol. 2005 Jun 15;174(12):7479; author reply 7479-80.
3. Ratajczak J, et al. Blood. 2004 Mar 15;103(6):2071-8.
4. Proctor LM, et al. Br J Pharmacol. 2004 Jun;142(4):756-64.
